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KMID : 1134820070360040439
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 4 p.439 ~ p.446
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Effects of Long-Term Administration of Saengshik on Growth Increment, BMD and Blood IGF-1 Concentration in Growing Rats
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Kim Joong-Hark
Hong Seong-Gil
Kim Wha-Young
Jung Ji-Sang
Hwang Sung-Ju
Mok Chul-Kyoon
Park Mi-Hyun
Lee Ju-Yeon
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Abstract
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This study was performed to investigate the effect of long-term administration of Saengshik on growth parameters of growing rats. Male Sprague-Dawley rats were fed on AIN-93G basal diets for 12 weeks and assigned to the following groups: rats administrated orally with Saengshik at the dose of 1 g/㎏/day (1xJS), 2 g/㎏/day (2xJS), 4 g/㎏/day (4xJS) and distilled water (Control). Rats were sacrificed at 4, 8, 12 weeks after oral administration. Bone mineral density (BMD) and bone mineral contents (BMC) were measured by PIXImus densitometry and serum insulin-like growth factor-1 (IGF-1) concentration were determined by using EIA method. Body weight and food intake did not show significant changes within groups for 12 weeks. Physical longitudinal growth indexes, body length and femur length were significantly increased in Saengshik-administered groups at 12 weeks, in which BMD and BMC also significantly increased. Also, in blood IGF-1 level, Saengshik -administered groups were remarkedly higher than control group at 4 week (p＜0.001), in which significantly higher at 8 week and 12 week. These results suggest a close relation between administration of Saengshik and increment of longitudinal bone growth. Therefore, as the result of this study, it could be expected that the administration of Saengshik for 12 weeks is helpful to the increase of longitudinal growth and growth factors in rats. Furthermore, we propose that the consumption of Saengshik as dietary supplementation may promote to increase in longitudinal bone growth in growing children.
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KEYWORD
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Saengshik, growth, BMD, BMC, IGF-1
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